Description
THE Graft™: Redefining Bone Regeneration in Nepal
THE Graft™ is a natural, porous bone mineral matrix derived from porcine bone. Through a precise process, all organic components are removed, resulting in an anorganic bone mineral that closely resembles the physical and chemical characteristics of the mineralized matrix in human bone.
When applied to a bone defect, THE Graft™ integrates effortlessly into the healing process. Its natural structure allows for progressive resorption and replacement with native bone, promoting effective and reliable regeneration.
Distinctive Features:
- Composition: Cancellous granules of natural bone mineral.
- Sterilization: Ensures utmost safety via gamma irradiation.
- Packaging: Convenient vials for easy and accurate application.
Scientific Validation:
The efficacy and safety of THE Graft™ are supported by extensive research, including:
- Laboratory and animal studies: Confirming biocompatibility and performance.
- Clinical case reports and trials: Large-scale evaluations in diverse conditions.
- Global reviews and meta-analyses: Demonstrating robust scientific backing.
A Global Phenomenon, Now in Nepal:
Widely recognized and trusted by practitioners worldwide, THE Graft™ is now available in Nepal through Skymed. Renowned for its scientific and clinical success, it is the preferred choice for bone regeneration, offering unparalleled outcomes for healthcare professionals and their patients.
THE Graft™ Biocomptability
« Getting closer to human bone »
The Graft™ is structurally similar to human tissue. It has high possible level of porosity combined with a natural interconnectivity.
Safe & Biocompatible
The combination of porcine origin with the high level of purity enables predictable bone growth without risking an immunogenic reaction. The high biocompatibility of THE Graft™ has been confirmed by an in-vitro cell study. THE Graft™ therefore encourages cell adhesion to the same extent as the established natural DBBM and offers optimal conditions for vital cell growth.
THE Graft™ Purity
Is THE Graft™ safe material ?
Patented proprietary virus inactivation process technology.
Thanks to highly efficient patented manufacturing process, THE Graft™ is free from any organic components that might be potential causes of infection or immune reaction. This unique process preserves most of the physical properties of the native porcine osseous structure of THE Graft™.
A large surface area is a key requirement for graft materials, and not only results in a larger surface region available for osteoblast cells attachment but also facilitates the exchange of nutrients and waste products, it allows greater amounts of blood, proteins, and growth factors to be absorbed onto the scaffold.
THE Graft™ Hydrophilicity
THE Graft™ consists of a unique inter-connection pore system that ensures an efficient fluid intake and permits the migration of cells. This pore system and high surface energy enhances the osteoconduction process.
The wettability of THE Graft™ turned out to be higher than compared existing xenografts, which suggests that THE Graft™ is relatively hydrophilic and can be easily wet by body fluids after implantation. Not only protein adsorption, but also the attachment, growth, and proliferation of various types of cells, including osteoblasts, have been reported to be significantly affected by the wettability of the material surface.
